Learning about cell lineage, cellular diversity and evolution of the human brain through stem cell models

Here, we summarize the current knowledge on cell diversity in cortex and other brain regions from vivo mouse models vitro based pluripotent stem cells. We discuss mechanisms underlying proliferation temporal progression that leads to sequential generation of neurons dedicated different layers cortex. highlight corticogenesis cells recapitulate specific transcriptional connectivity patterns cortical areas. overview state-of-the art human organoids modeling regions, insights into evolution Finally, interrogate organoid for their competence essence development.